Definition of amyloidosis
Amyloidosis is a disease in which amyloid proteins accumulate in organs and tissues. Protein is considered to be amyloid, which, due to its three-dimensional structure change, is massive and insoluble, similar to the beta sheet.
Causes and risk factors for amyloidosis
Amyloidosis can be caused by different causes. The causes of primary amyloidosis are abnormal production of immunoglobulins.
Secondary amyloidosis in multiple myeloma, rheumatoid arthritis, inflammatory bowel disease, familial Mediterranean fever. Secondary amyloidosis is also present in chronic infectious diseases such as leprosy and tuberculosis.
Familial amyloidosis is an autosomal dominant disease. Aging amyloidosis is the most common cause of amyloid cardiomyopathy in the elderly. One of the symptoms of this paresthesia is that the ends of the limbs are due to metabolic neuropathy.
Chemical indicators show several types of fibrelic amyloid with different clinical conditions:
– Amyloidosis (AL): The most common form of systemic amyloidosis is seen in clinical medicine. Initial idiopathic amyloidosis and amyloidosis associated with multiple myeloma.
Amyloid amyloidosis AA (A): Secondary amyloidosis and as a side-effect of chronic inflammatory disease and familial Mediterranean fever (FMF).
Family hereditary amyloidosis (Heredofamilial Amyloidoses)
– Aβ2M: Amyloid associated with chronic hemodialysis. Similar to β2 microglobulin.
Localized or limited limb amyloidosis: Contains Aβ: in norethicle platelets and cerebellar walls of patients with Alzheimer’s disease and Down syndrome.
Symptoms of amyloidosis
In the disease, amyloid gradually builds up in the organs for a long time (years) and causes symptoms that depend on the affected organ.
For example, if amyloid is accumulated in the kidneys, it may lead to chronic renal failure, which is usually accompanied by the accumulation of (unrefined) fluids in the body, fatigue, weakness and diarrhea. The accumulation of amyloid in the heart causes it to become large and unable to pump blood throughout the body, resulting in heart failure, shortness of breath and accumulation of fluid in the body.
Amyloidosis can cause the following symptoms:
· Weight Loss
· The accumulation of fluids in the body called “edema”.
· Shortness of breath
· Sleepiness and constant disregard
· Anesthesia or tingling of the hands and feet
· Humorous sound
Language tongue with blisters or blisters
Detection of amyloidosis
Detection of amyloidosis can sometimes be difficult, because its symptoms are often very general, which may also be seen in many other illnesses. Diagnosis can be done by biopsy (tissue sampling) and observing it under a microscope.
Treatment of amyloidosis
There is no specific treatment for any type of amyloidosis. If there is a teratogenic disease, it should be treated. Primary amyloidosis may respond to prednisone and alkylated drug regimens, probably due to the effects of these drugs on the synthesis of amyloid AL protein.
Colchicine (2-1 mg / d) can prevent FMF acute attacks. Therefore, the amyloid deposit may be interrupted. It may be effective in renal transplant patients.